Gene program-specific regulation of PGC-1 activity
نویسندگان
چکیده
منابع مشابه
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.
Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) plays a major role in mediating hepatic gluconeogenesis in response to starvation, during which PGC-1 is induced by the cyclic AMP response element binding protein. Although it is observed that insulin counteracts PGC-1 transcription, the mechanism by which insulin suppresses the transcription of PGC-1 is still unclear. Here...
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Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1 . Am J Physiol Endocrinol Metab 296: E543–E548, 2009. First published January 21, 2009; doi:10.1152/ajpendo.90719.2008.—Plasma homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Hcy is a nonprotein amin...
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Skeletal muscle tissue shows an extraordinary cellular plasticity, but the underlying molecular mechanisms are still poorly understood. Here, we use a combination of experimental and computational approaches to unravel the complex transcriptional network of muscle cell plasticity centered on the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a regulatory nexus in enduranc...
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PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of mitochondrial dysfunction including abundant abnormal mitochondria, reduced respiratory subunit expression, diminished respiratory enzymes and ATP levels, and e...
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Background: Students with specific learning disorder are faced with various physical and psychological stressful factors, that affect their quality of life. Considering the relationship between academic anxiety and self-regulation, as one of the methods capable of assisting students with specific learning disorder is self-regulation empowerment training. The current study aimed at determining t...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369
DOI: 10.1101/gad.2076411